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제목 한국 한센사업대상자의 C형 간염 혈청검사 양성률
저자 김종필, 강국형, 박진모 소속 한국한센복지협회 연구원
년도 2018 51
1 번호 2
시작페이지 13 끝페이지 21
첨부 한국한센사업대상자C형간염혈청검사양성률-r1.pdf
요약 Background
Leprosy is a contagious chronic granulomatous disease and is a disease that is associated with defects in
cellular immunity. A high prevalence of hepatitis C virus infection in leprosy patients has been reported in
several African countries, Yemen, Brazil and Japan. In Korea, it’s seropositivity was reported as 8.33%(2001),
39.3%(2002), 35.1%(2009) and 16.0%(2009) on Korean Leprosy Bulletin.

Objective
In the meantime, the studies were limited to the subjects in a specific region, and the number of subjects was
not enough, so it was not enough to evaluate the hepatitis C virus seropositivity of persons affected by leprosy
in Korea. So this study was conducted to evaluate the it’s seropositivity in settlement villages nationwide.

Method
This study was conducted that the mobile team visited the resettlement villages nationwide from 2009 to 2017
and conducted on persons affected by leprosy and residents residing in resettlement village. Obtained serums
were assayed by the ADVIA Centaur HVC(IgG antibodies to Hepatitis C Virus) reagent using a Siemens ADVIA
Centaur CP instrument. The results of persons affected by leprosy and residents were compared, and the
difference of seropositivity among the groups(male and female, multibacillary and paucibacillary, locations of
resettlement villages) was evaluated.

Result
The results of hepatitis C virus antibody positivity of 1669 persons affected by leprosy subjects and 185
residents of resettlement villages were 28.46% in persons affected by leprosy and 6.49% in residents(Pearson's
Chi-Square test, P = 0.00). In persons affected by leprosy, that were 31.99%(male) and 26.84%(female)
(Pearson's Chi-Square test, P = 0.06) and were 29.97%(multibacillary) and 25.36%(paucibacillary)(Pearson's
Chi-Square test, P = 0.05). That of Seoul(48.28%), Busan(43.78%) and Chungbuk Province(35.94%) were
highly positive and that of Gangwon Province(20.34%) was lowly positive(Fisher's Exact test P = 0.002).

Conclusion
In this study, we found that hepatitis C virus antibody positivity rate was high in persons affected by leprosy in Korea. In order to explain the high positive rate, further studies will be needed. Also, through various approaches including assessment of HCV RNA to the subjects who were judged to be positive for antibody test in the future, a comprehensive evaluation of hepatitis C and its countermeasures are needed.
▪ Key Words : Hepatitis C virus, Leprosy, Seropositivity
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